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. Author manuscript; available in PMC: 2015 Nov 19.
Published in final edited form as: Sci Transl Med. 2014 Nov 19;6(263):263ra161. doi: 10.1126/scitranslmed.3010382

Fig. 1. BPH-1222 and zoledronate bind to the same site of FPPS.

Fig. 1

(A) Zoledronate. (B) A library of zoledronate analogs, side-chain length n= 0–15, X= H or OH. (C) BPH-1222. (D) Structure of BPH-1222 binding to FPPS was determined by single crystal X-ray crystallography. Zoledronate binding is shown superimposed with BPH-1222 (zoledronate in yellow and BPH-1222 in cyan).