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. Author manuscript; available in PMC: 2016 Jan 22.
Published in final edited form as: Neuroscience. 2014 Oct 18;284:601–610. doi: 10.1016/j.neuroscience.2014.10.021

Figure 1.

Figure 1

A: Schematic representation of the experimental design. Subdural EEG electrodes were implanted, and 1 week later LiCl (127 mg/Kg) was injected i.p. The following day, scopolamine bromide (1 mg/kg, ip) was administered 30 min before the injection of pilocarpine (50 mg/kg, ip). The drugs (NS-398 and/or diazepam, 10 mg/kg each) and the vehicle were administered 30 min after the first motor seizure. NS-398/vehicle injections were repeated 6 h later. Rats were sacrificed 24 h after induction of SE. B: Electrographic SE was considered to be the period of time in which the animal displayed continuous spiking without periods of inactivity between spiking.