Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 3;14(1):23. doi: 10.1186/s12943-015-0303-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Lee et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Effects of inhibition of IL-6 signaling on proliferation and colony-formation of LHB-expressing cells. (A) Phosphorylated stat3, stat3 and actin were analyzed by immunoblotting. (B) Designated cells were treated with JSI-124 (10 μM), a Jak2 inhibitor, and their proliferation was assessed. (C) Colony-forming ability of LHB-expressing cells was examined by a colony forming assay in the absence or presence of JSI-124. (D and E) Cells were transfected with siRNAs (200 nM) targeting JAK2 (D), stat3 (E) or control scrambled siRNAs as indicated. Cells proliferation was analyzed by MTT assay. Data represent means ± SD. **P < 0.01, ***P < 0.001.