Table 1.
Distribution of clinical manifestations of drug hypersensitivity from " Test A " group (values are given in % of cases)
| IL-6 release pattern | |||||
|---|---|---|---|---|---|
| Phenotypes | with peak at 0.15 μM, (n = 37 tests) I | with peak at 0.35 μM, (n = 67 tests) II | with peak at 0.5 μM, (n = 38 tests) III | with 2 or more positivities (n = 65 tests) IV | |
| 1 | Generalized urticaria ± ANO2 | 17 | 18 | 11 | 18 |
| 2 | Systemic Anaphylaxis ± ANO | 23 | 24 | 24 | 28 |
| 3 | DRESS3 (culprit/non-culprit*) | 3 | 0 | 3* | 0 |
| 4 | Generalized MPE4 (>18%) | 14 | 16 | 8 | 20 |
| 5 | Localized MPE (<18%) | 6 | 4 | 8 | 5 |
| 6 | Disseminated fixed drug eruption | 1 | 2 | 0 | 0 |
| 7 | Erythema multiforme | 0 | 2 | 0 | 2 |
| 8 | Asthma, severe itch | 1 | 0 | 0 | 0 |
| 9 | Generalized disseminated dermatitis | 9 | 2 | 11 | 8 |
| 10 | Small patchy urticaria | 3 | 9 | 8 | 5 |
| 11 | Localized ANO | 14 | 17 | 18 | 8 |
| 12 | Leg dermatits ± purpurae | 0 | 3 | 3 | 5 |
| 13 | Circumscribed vesiculae | 3 | 0 | 3 | 0 |
| 14 | Erythema annulare centrifugum/E.nodosum | 6 | 3 | 3 | 1 |
2ANO- angioneurotic edema.
3DRESS –drug rash with eosinophilia and systemic symptoms.
4MPE- maculopapular exanthema.
*non-culprit drug representation of a single case.
Boldface number in column II marks culprit.