Table 2.

Summary data for variants rs1975649, rs11008222 and rs8061121 in left-sided lesions in Stages 1 and 2

SNP (genotyped/imputed in Stage 1)	Chra	MAFb	Positionc (bp)	Gened	Function	P-values			Genotype relative riske (95% confidence interval)
						Stage 1	Stage 2	Stage 1 + 2	Stage 1	Stage 2	Stage 1 + 2
Inherited effects
rs8061121 (imputed)f	16	0.11	85750585	(AC136285.1)	Intergenic	2.44 × 10−7	0.005	4.04 × 10−9	2.94 (1.91–4.54)	2.16 (1.24–3.76)	2.65 (1.89–3.71)
rs1975649 (genotyped)	3	0.33	63413926	SYNPR	Intron	1.08 × 10−6	0.03	3.38 × 10−7	1.87 (1.45–2.43)	1.38 (1.03–1.87)	1.65 (1.36–2.01)
Maternal effects
rs11008222 (genotyped)	10	0.49	31082750	(ZNF438)	Intergenic	9.60 × 10−6	0.02	6.27 × 10−7	1.68 (1.32–2.13)	1.55 (1.06–2.26)	1.64 (1.34–2.00)

^aChromosome.

^bMAF among study participant founders (i.e. mother and father).

^cHg18/NCBI build 36.

^dFor SNPs mapping within genes, gene names are listed, and for intergenic SNPs, the nearest gene is listed in parentheses.

^eRelative risk estimate for carrying one copy of the high-risk allele compared to no copies, and corresponding 95% confidence interval.

^fP-value for this variant in Stage 1 is based on the analyses of the subgroup of non-Hispanic Caucasian triads.