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. 2014 Sep 8;24(1):185–196. doi: 10.1093/hmg/ddu428

Figure 6.

Figure 6.

Cln1R151X mice have motor deficits as measured by the vertical pole test and rotarod test. The motor skills of WT and Cln1R151X male mice were examined at 3 and 5 months of age. (A) In the modified vertical pole test, Cln1R151X mice climbed down on the pole drastically slower (upper 2 graphs), and turned downward on the pole significantly slower (lower 2 graphs) than WT mice. Columns and bars represent mean ± SEM. The same WT and Cln1R151X mice were tested at 3 and 5 months of age (14 WT and 12 Cln1R151X mice). Statistical significance was determined by the non-parametric Mann–Whitney test. (B) In an accelerating rotarod test (0.2 rpm/s starting from 0 rpm), 3-month-old Cln1R151X mice fell from the rotating rod 31 s sooner than WT mice (left graph). At the age of 5 months, the rotarod performance of Cln1R151X and WT mice was similar (right graph). Columns and bars represent mean ± SEM. The same WT and Cln1R151X mice were tested at 3 and 5 months of age (14 WT and 12 Cln1R151X mice). Statistical significance was determined by unpaired t-test.