Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Working model of CNGA1-associated PI3Kγ activation. The CNG channel is localized to the plasma membrane of the rod photoreceptor cells. We propose that the RA-domain of PI3Kγ associates with the RLD-domain of CNGA1, and it will thereby have a close proximity to its substrates. PI3Kγ-generated PIs activate the downstream effectors and thereby regulate various aspects of photoreceptor functions.
