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. 2015 Feb 4;15(1):16. doi: 10.1186/s12935-015-0165-5

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© Liu and Huang; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Beclin-1 was a direct target of miR-191. (A) Schematic representation of the 39- UTR of human Beclin-1 transcript. Predicted miR-191 binding site was depicted. The numbers (+121–140) represented the nucleotides that were predicted to base pair with the miR-191 seed sequence. (B) The expression of miR-191 in radiation-resistant A549 cells with or without Beclin-1 mutation (*p <0.05 vs control, n = 3). (C) The expression of miR-191 in radiation-resistant H1299 cells with or without Beclin-1 mutation (*p <0.05 vs control, n = 3).