Fig. 10.

Activation of BV2 microglia could trigger a strong inflammatory reaction in PC12 cell apoptosis by toll-like receptor signaling pathway. LPS-treated BV2 microglia had increased levels of TLR4, MyD88, NF-κB, and release of inflammatory mediator IL-1 β significantly increased. The inflammatory mediator up-regulated Bax to Bcl-2 ratio to promote PC12 cell apoptosis and injury. IL-1RA pretreatment protected PC12 cell from IL-1β-induced injury through down-regulating Bax to Bcl-2 ratio to suppress apoptosis