Fig. 7.

Molecular model showing the ASF1-SWI/SNF cooperation in nucleosome disassembly at yeast heat shock gene promoters during the acute stress and FACT complex participation in nucleosome reassembly during the attenuation phase. a Processes in the WT strain: ASF1 and SWI/SNF complex cooperate in the process of nucleosome removal leading to the increased molecular chaperone expression during the acute stress, while FACT participates in nucleosome reassembly leading to the shutdown of transcription. b Inactivation of FACT leads to incomplete nucleosome reassembly and partial expression of molecular chaperones during the attenuation phase, thus causing a synthetic thermotolerance