Fig. 6.

The Aβ channel blocker NA7 prevents the slow increase in intracellular calcium concentration in neurons. Single-cell measurement of intracellular [Ca²⁺] levels in the cells exposed to Aβ42 alone (red lines) and Aβ42 plus NA7 (blue lines) after 3 days. Continuous exposure to Aβ42 creates a subpopulation of cells with cytosolic calcium levels higher than average. NA7, a specific Aβ channel blocker small peptide, reduces the size of this subpopulation and the amplitude of calcium elevation. The bar plot of the averaged free cytosolic calcium of the whole cell population shows a significant protection by NA7 but does not reveal the absolute protection by NA7 on the subpopulation of neurons that suffered the lowest calcium increases