Fig. 7.

Western blot analysis to measure the effects of different concentrations of geldanamycin (GA), i.c.v. administration of 1 μg and 2 μg/kg, on caspase-3 and PARP cleavage in the hippocampus of Aβ-injected rats. a Sixty micrograms of proteins were separated on SDS-PAGE, Western blotted, probed with specific primary antibodies and reprobed with anti β-actin antibody (Western blot was repeated two times for each animal; n = 3). b The densities of caspase-3 bands were measured and their ratios to β-actin bands were calculated. c The densities of PARP bands were measured and their ratios β-actin bands were calculated. Each point shows the mean ± SEM. **P < 0.01; ***P < 0.001 compared to control group. ^# P < 0.05; ^## P < 0.01 compared to the Aβ-injected group