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. 2015 Feb 6;15:35. doi: 10.1186/s12885-015-1035-1

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© Hansen et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Co-amplification of chromosome 17 centromere andHER2. SNP data from tumor sample 26 displaying the copy number and allele ratios across chromosome 17. This sample has undergone multiple DNA breaks and several regions of the chromosome 17q arm are amplified, including a region around HER2 (4.46-fold) and a region close to the centromere. The two regions are amplified to the same extent and may therefore explain the negative IHC HER2/CEP17 even though the HER2 gene is clearly amplified.