Table 5.

Cross-sectional analysis: percent change (95% CIs) in thyroid hormone concentrations in relation to interquartile range increase in urinary phthalate metabolite concentration by visit during gestation

Visit 1 (16–20 weeks)
Analyte	% Change (95% CI)	p-value	% Change (95% CI)	p-value	% Change (95% CI)	p-value
	Free T3 (n = 100 observations)		Free T4 (n = 100 observations)		ln-TSH (n = 100 observations)
MBzP	1.87 (-2.55, 6.37)	0.40	2.44 (-2.77, 7.65)	0.36	12.9 (-0.93, 28.2)	0.07†
MBP	-0.72 (-4.94, 3.29)	0.73	0.26 (-4.58, 5.04)	0.92	1.29 (-10.2, 13.7)	0.83
MiBP	-1.64 (-5.55, 2.42)	0.43	4.95 (0.27, 9.28)	0.04*	1.09 (-10.3, 13.9)	0.86
MEP	-0.20 (-5.37, 5.02)	0.94	-0.05 (-6.10, 6.10)	0.99	0.77 (-13.6, 17.7)	0.92
MCPP	-1.04 (-4.54, 2.62)	0.57	1.41 (-2.83, 5.80)	0.50	-2.57 (-12.7, 8.69)	0.64
MCOP	-0.50 (-4.11, 2.93)	0.78	-0.44 (-4.58, 3.76)	0.83	-0.39 (-10.3, 10.7)	0.94
MCNP	1.05 (-2.27, 4.49)	0.53	0.43 (-3.47, 4.37)	0.83	-2.68 (-11.9, 7.35)	0.58
ΣDEHP	-1.62 (-6.05, 2.85)	0.47	3.09 (-2.17, 8.27)	0.25	7.14 (-6.12, 22.3)	0.30
Visit 3 (24–28 weeks)
	Free T3 (n = 81 observations)		Free T4 (n = 81 observations)		ln-TSH (n = 81 observations)
MBzP	-2.67 (-8.3, 2.86)	0.34	-2.97 (-12.1, 6.07)	0.51	-4.62 (-20.4, 13.5)	0.58
MBP	-0.57 (-5.68, 4.34)	0.82	-1.46 (-9.67, 6.74)	0.72	9.57 (-6.27, 27.3)	0.25
MiBP	-2.51 (-6.81, 1.70)	0.24	-4.70 (-11.8, 2.08)	0.17	2.74 (-9.94, 17.9)	0.68
MEP	2.76 (-2.68, 8.44)	0.32	4.93 (-3.81, 13.7)	0.27	18.1 (0.00, 37.8)	0.05†
MCPP	-5.93 (-10.2, -1.75)	0.01*	-5.11 (-12.5, 2.22)	0.17	2.41 (-11.1, 17.7)	0.74
MCOP	-5.83 (-10.8, -0.58)	0.03*	-3.02 (-11.5, 5.38)	0.47	-3.35 (-17.1, 13.6)	0.67
MCNP	-1.44 (-5.92, 3.10)	0.54	-6.34 (-14.0, 0.99)	0.09†	5.39 (-8.50, 21.3)	0.46
ΣDEHP	0.05 (-4.49, 4.49)	0.98	-8.02 (-15.3, -0.80)	0.03*	2.79 (-10.8, 18.6)	0.70

CI, confidence interval, TSH, thyroid-stimulating hormone. Linear regression models adjusted for age at enrollment, prepregnancy body mass index, and urinary specific gravity.

*P < 0.05.

†P < 0.10.