Table 2.
Allele frequencies and genotype distributions of miR-146a C > G, miR-149 T > C, miR-196a2 T > C and miR-499 T > C SNPs in the Chinese Uygur population
| SNP sites | Controls N (Freq) | Patients N (Freq) | P value | OR (95% CI) | |
|---|---|---|---|---|---|
| miR-146a C > G Allele | G | 441(0.611) | 358(0.622) | 0.693 | 1 0.96(0.76-1.20) |
| C | 281(0.389) | 218(0.378) | |||
| Genotype | GG | 131(0.368) | 106(0.368) | 1 | |
| GC | 179(0.496) | 146(0.507) | 0.963 | 1.00(0.72-1.41) | |
| CC | 51(0.141) | 36(0.125) | 0.591 | 0.87(0.53-1.43) | |
| HWE(P) | 0.415 | 0.188 | |||
| miR-149 T > C Allele | C | 342(0.521) | 274(0.511) | 0.727 | 1 1.04(0.83-1.31) |
| T | 314(0.479) | 262(0.489) | |||
| Genotype | CC | 89(0.271) | 75(0.280) | 1 | |
| TC | 164(0.500) | 124(0.164) | 0.581 | 0.89(0.61-1.32) | |
| TT | 75(0.229) | 69(0.257) | 0.701 | 1.09(0.69-1.71) | |
| HWE(P) | 0.974 | 0.225 | |||
| miR-196a2 T > C Allele | C | 378(0.531) | 286(0.498) | 0.244 | 1 1.14(0.91-1.42) |
| T | 334(0.469) | 288(0.502) | |||
| Genotype | CC | 96(0.270) | 67(0.233) | 1 | |
| TC | 186(0.522) | 152(0.530) | 0.414 | 1.17(0.80-1.71) | |
| TT | 74(0.208) | 68(0.237) | 0.234 | 1.32(0.84-2.07) | |
| HWE(P) | 0.356 | 0.316 | |||
| miR-499 T > C Allele | T | 421(0.829) | 455(0.756) | 0.003 | 1 1.56(1.16-2.10) |
| C | 87(0.171) | 147(0.244) | |||
| Genotype | TT | 171(0.673) | 176(0.585) | 1 | |
| TC | 79(0.311) | 103(0.342) | 0.199 | 1.27(0.88-1.82) | |
| CC | 4(0.016) | 22(0.073) | 0.001 | 5.34(1.80-15.83) | |
| HWE(P) | 0.127 | 0.205 | |||
SNP: single nucleotide polymorphism, HWE: Hardy-Weinberg equilibrium, OR: odds ratio, CI: confidence interval, N: number of alleles, Freq: frequency. All of the miRNA SNPs were in HWE.