Table 3.
Allele frequencies and genotype distributions of miR-146a C > G, miR-149 T > C, miR-196a2 T > C and miR-499 T > C SNPs in the Chinese Kazak population
| SNP sites | Controls N (Freq) | Patients N (Freq) | P value | OR (95% CI) | |
|---|---|---|---|---|---|
| miR-146a C > G Allele | G | 422(0.598) | 284(0.402) | 0.023 | 1 1.33(1.04-1.69) |
| C | 222(0.529) | 198(0.171) | |||
| Genotype | GG | 124(0.351) | 65(0.310) | 1 | |
| GC | 174(0.493) | 92(0.438) | 0.965 | 1.01(0.68-1.49) | |
| CC | 55(0.156) | 53(0.252) | 0.013 | 1.84(1.14-2.98) | |
| HWE(P) | 0.637 | 0.080 | |||
| miR-149 T > C Allele | T | 437(0.604) | 189(0.580) | 0.466 | 1 1.10(0.84-1.44) |
| C | 287(0.396) | 137(0.420) | |||
| Genotype | TT | 131(0.362) | 52(0.319) | 1 | |
| TC | 175(0.483) | 85(0.521) | 0.338 | 1.22 (0.81-1.85) | |
| CC | 56(0.155) | 26(0.160) | 0.587 | 1.17 (0.66-2.06) | |
| HWE(P) | 0.845904 | 0.370294 | |||
| miR-196a2 T > C Allele | C | 378(0.549) | 314(0.625) | 0.008 | 1 0.73(0.58-0.92) |
| T | 310(0.451) | 188(0.451) | |||
| Genotype | CC | 103(0.299) | 99(0.394) | 1 | |
| TC | 172(0.500) | 116(0.462) | 0.055 | 0.72(0.49-1.01) | |
| TT | 69(0.201) | 36(0.143) | 0.013 | 0.54(0.33-0.88) | |
| HWE(P) | 0.855 | 0.830 | |||
| miR-499 T > C Allele | T | 382(0.813) | 285(0.828) | 0.565 | 10.90(0.62-1.29) |
| C | 88(0.187) | 59(0.172) | |||
| Genotype | TT | 157(0.668) | 116(0.674) | 1 | |
| TC | 68(0.298) | 53(0.308) | 0.808 | 1.06(0.68-1.62) | |
| CC | 10(0.043) | 3(0.017) | 0.165 | 0.41(0.11-1.51) | |
| HWE(P) | 0.450 | 0.269 | |||
SNP: single nucleotide polymorphism, HWE: Hardy-Weinberg equilibrium, OR: odds ratio, CI: confidence interval, N: number of alleles, Freq: frequency. All of the miRNA SNPs were in HWE.