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. 2015 Feb 5;16(1):13. doi: 10.1186/s12931-015-0183-9

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© Wen et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Denatonium reduces mitochondrial membrane potential. A) The TEM microphotographs show the ultrastructure of control cells (a1,a2) and denatonium (2 mM, 72 h) treated A549 cells (b1, b2, b3). Swollen mitochondria (***) were observed in treated cells (b2, b3). B) A549 cells were stained with the cationic lipophilic dye, JC-1 and analyzed by FACS after treatment with denatonium for 72 h. C) 16HBE cells were stained with the cationic lipophilic dye JC-1 and analyzed by FACS after treatment with denatonium for 24 h. The figures are representative profiles of at least three experiments. The histogram shows the quantification of mitochondrial membrane potential. (**p < 0.01, ***p < 0.001).