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. 2015 Feb 5;16(1):13. doi: 10.1186/s12931-015-0183-9

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© Wen et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Denatonium down-regulates the expression of the anti-apoptotic protein Bcl-2 and enhances the release of cytochrome c and Smac/DIABLO from mitochondria in 16HBE cells. A) The expression of the anti-apoptotic protein Bcl-2 was significantly reduced in 16HBE cells after treatment with denatonium for 24 h. B) In 16HBE cells treated with denatonium for 24 h, the cytochrome c and Smac/DIABLO levels in mitochondria were significantly reduced, whereas, the cytochrome c and Smac/DIABLO levels in cytosol were significantly increased (C). The figures are representative profiles of at least three experiments. (***p < 0.001).