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. 2015 Jan 13;16(1):5. doi: 10.1186/s13059-014-0575-z

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© Tomaselli et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Altered expression of mature and primary miR-221, -222 and -21 in wild-type and Adar2 ^-/- mouse brain tissue. (a) Mature miR-221 (left panel), miR-222 (middle panel) and miR-21 (right panel) expression levels were analyzed using specific qRT-PCRs in wild-type (WT, dark gray) and Adar2 ^-/- (medium gray) mouse brain tissue. (b) Primary miR-221 (left panel), pri-miR-222 (middle panel) and pri-miR-21 (right panel) expression levels were measured using specific qRT-PCRs in the same samples. Mature miRNAs were normalized to RNU6B and pri-miRNAs were normalized to β-actin levels. The expression levels were calculated as a relative-fold increase compared with the wild-type samples arbitrarily set to 1. Mean ± standard error of the mean (n = 3), **P < 0.01, *P < 0.05.