Table 1.

ADAR2-mediated editing events in brain and glioblastoma cells and tissues

Chr	Strand	miRNA	U118	ADAR2	ADAR2 E/A	siADAR2	P -value	Pooled human brain	Human frontal lobe	Glioblastoma	Location in pre-miR	Location in mature miR
Chr9	+	hsa-let-7d*	0.3	2.0	0	0.5	1.61E-10	1.2	0.7	0	66	5
Chr17	-	hsa-mir-22	0	0.1	0	0.1	5.50E-34	0	0	0	67	15
Chr19	-	hsa-mir-24–2*	0.1	16.4	0	7.1	<1E-155	0.8	2.3	ND	18	6
Chr19	-	hsa-mir-27a*	0.1	22.5	0.1	9.8	<1E-155	ND	0	2.6	10	1
Chr21	+	hsa-mir-99a	0.1	13.8	0	6.9	<1E-155	5.0	1.2	0	13	1
Chr11	-	hsa-mir-100	0	0.2	0	0.1	1.22E-145	0	0	0	13	1
Chr3	+	hsa-mir-138–1*	0	0.8	0	0.5	2.57E-35	2.1	0.2	ND	74	12
Chr8	-	hsa-mir-151	0.1	0.3	0	0.2	5.70E-13	0.9	0.6	ND	49	3
Chr11	-	hsa-mir-210	0	0.5	0	0.5	2.31E-11	ND	ND	0	77	12
Chr14	+	hsa-mir-411	0	12.6	0	5.6	4.31E-39	15.3	13.9	3.2	20	5
Chrx	-	hsa-mir-421	0.2	13.8	0.5	9.6	<1E-155	1.8	1.0	0	61	14
Chr9	+	hsa-mir-455	0	14.2	0	5.7	<1E-155	1.2	0.9	0	32	17
Chr17	-	hsa-mir-497	0	26.1	0	16.7	1.73E-155	6.2	0.6	0	25	2
Chrx	-	hsa-mir-503	0	5.9	0	1.7	8.75E-14	ND	ND	0	7	2
Chr7	-	hsa-mir-589*	2.3	9.5	2.2	2.9	1.36E-31	70.0	74.1	0	66	6
Chr19	-	hsa-mir-641	0	17.0	0	8.8	5.83E-116	0	0	0	17	2
Chr19	-	hsa-mir-641	0	3.0	0	0.9	2.45E-14	0	3.6	0	18	3
Chr10	-	hsa-mir-3157*	0	69.4	0	54.5	1.55E-90	ND	ND	0	70	13
Chr16	+	hsa-mir-3176	0	10.9	0	8.2	6.73E-41	ND	ND	0	74	15

A-to-G changes in mature miRNAs isolated from U118 cell lines (untreated, ADAR2, ADAR2 E/A, siADAR2), human brains (pooled and frontal lobe) and glioblastoma. The statistically significant modifications are marked in bold; the edited miRNAs that were not identified in our previous analysis are indicated in italics [23]; miRNAs that are both edited and modulated by ADAR2 are indicated in bold (Additional files 2 and 3).

Editing levels are represented as percentages. ND, not determined (with <10 reads).