Table 1.
Epidemiologic characteristics, endozepine, biomarkers of inflammation and cytokine levels of healthy volunteers and patients with inflammation a
| Healthy volunteers ( n = 16) | Patients with inflammation ( n = 44) | |
|---|---|---|
| Age (yr) | 37.0 [29 to 45] | 44 [28 to 60]b |
| Sex, n (M/F) | 8/8b | 23/21 |
| Weight (kg) | 61 [59.5 to 71] | 71 [62 to 80]b |
| APACHE II score | NA | 3 [2–6] |
| Length of stay (days) | NA | 5 [4–8] |
| Creatinine (μ mol/L) | UM | 72 [61 to 79] |
| DBI-LI (pg/ml) | 11.1 [5.9 to 35.3] | 48.6 [32.7 to 77.7]c |
| PMN (×10 3 /ml) | UM | 9.2 [6.7 to 13] |
| CRP (mg/L) | UM | 189 [132 to 279] |
| PCT (μ g/L) | UM | 0.25 [0.16 to 1.4] |
| TNF-α (pg/ml) | 6.1 [3.1 to 13.7] | 4.2 [2.9 to 5.7]b |
| IL-1β (pg/ml) | UD | 0.37 [0.12 to 0.69] |
| IL-6 (pg/ml) | UD | 48.7 [17.6 to 79.7] |
aThe results are expressed as median and 25th to 75th interquartile range. bNot statistically different from healthy volunteers; c P < 0.001 vs healthy volunteers. APACHE II, Acute Physiology and Chronic Health Evaluation II; CRP, C-reactive protein, DBI-LI, Diazepam-binding inhibitor–like immunoreactivity; IL, Interleukin; NA, Not applicable, PCT, Procalcitonin; PMN, Polymorphonuclear neutrophils; TNF-α, Tumor necrosis factor α; UM, Unmeasured; UD, Undetectable.