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. 2015 Feb 4;15(1):5. doi: 10.1186/s12935-014-0151-3

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© Lam et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Induction of Noxa mRNA and protein in H292 cells treated with albendazole and mebendazole. (A) H292 cells were treated with or without 10 μM albendazole or mebendazole for 1 day. Cell lysate was prepared and Noxa, Bim, Puma, Mcl-1, Bcl-x_L, and HPRT mRNA was measured using a branched DNA assay. The expression of these genes was normalized to HPRT control and no treatment control. (B) H292 cells were treated with increasing concentrations (0–10 μl) of albendazole and mebendazole for 2 days. Cell lysate was prepared and resolved on a 12% SDS polyacrylamide gel and probed with anti-Bim, anti-Noxa, and anti-Mcl-1. Antibody against actin was used as loading control. Data shown are representative of two independent experiments.