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. Author manuscript; available in PMC: 2015 Aug 12.
Published in final edited form as: Nature. 2014 Nov 17;518(7538):240–244. doi: 10.1038/nature13948

Figure 2. Loss of PTEN upon BYL719 resistance.

Figure 2

a, Circos plots from WGS analysis of primary tumour (prior to BYL719 treatment) and a lung metastasis appearing after the tenth cycle of BYL719 therapy. b, CNV of chromosome 10. c, WES of the peri-aortic lymph node showing durable stable disease during BYL719 therapy compared to both primary tumour and the progressing lung lesion. The diagram shows the variation of allele frequencies (VAF) of the listed gene mutations in the three lesions. The estimated tumour purities are 44% for the breast primary tumour, 50% for the lung metastasis, and 59% for the lymph node metastasis. d, PTEN IHC of primary tumour, peri-aortic lymph node, and lung metastasis. Images were taken from Servier Medical Art.