Table 2.
Patient | Gender | Cancer Type | Age at Radiation Therapy | Radiation Dose (cGy) | Radiation Field | ICM location | Interval of f/u MRI (year) | Time to ICM detection† (years) | Age at ICM detection (years) |
---|---|---|---|---|---|---|---|---|---|
1 | male | MB | 6 | 6100 | whole brain | left frontal periventricular | 1 | 1 | 7 |
2 | female | MB | 7 | 6055 | posterior fossa | left parietal | 1 | 6 | 13 |
3 | female | PA | 7 | 5800 | posterior fossa | left inferior temporal | 1 | 12 | 20 |
4* | male | PA | 8 | 5580 | right frontal | right frontoparietal | 1 | 19 | 28 |
5* | male | MG | 8 | 5400 | left temporal | left temporal lobe | 2 | 13 | 21 |
6 | male | AA | 10 | 5940 | whole brain | bilateral thalami | 1 | 6 | 16 |
7 | male | BL | 11 | 2400 | frontal | frontal subcortical | 0 | 14 | 26 |
8 | male | MEC | 14 | 5760 | parotid | right frontal lobe | 1 | 4 | 19 |
9 | male | PA | 15 | 5580 | whole brain | right periventricular | 0 | 24 | 39 |
10* | male | PA | 16 | 6600 | right temporal | right temporal parietal | 2 | 11 | 28 |
These patients received surgical resection for symptomatic ICM (Patient 4: seizures and headache; Patient 5: headache; Patient 10: L sided numbness, weakness and facial droop)
presented as years after cranial radiation therapy.
AA = Anaplastic astrocytoma, BL = Burkitt's lymphoma, PA = pilocytic astrocytoma, MB = medulloblastoma, MEC = mucoid epidermal carcinoma, MG = mixed germinoma