Table 1.
HIV viral kinetics estimated by fitting Eq. [1] to each patient’s viral load.
| V0 Log10(IU/ml) |
t0 days |
δ days−1 |
δM days−1 |
π0 days−1 |
ALT flare in the first 20 weeks? | |
|---|---|---|---|---|---|---|
| CIN01 | 5.05 | 0.51 | 0.56 | 0.04 | 0.98 | Yes |
| CIN02 | 4.65 | 1.10 | 1.20 | 0.03 | 0.97 | No |
| CIN03 | 5.63 | 0.75 | 0.74 | 0.02 | 0.98 | Yes |
| CIN04* | 2.14 | 0.78 | 0.22 | NA (rebound) | NA (rebound) | No |
| CIN05 | 4.28 | 0.98 | 0.73 | 0.01 | 0.97 | Yes |
| CIN06 | 5.45 | 0.99 | 0.56 | 0.03 | 0.99 | Yes |
| CIN07 | 3.77 | 0.37 | 1.00 | 0.08 | 0.96 | No |
| CIN08 | 3.98 | 0.39 | 0.99 | 0.00 | 0.98 | Yes |
| CIN09 | 4.47 | 0.18 | 0.93 | 0.07 | 0.97 | No |
| CIN10 | 4.91 | 0.89 | 1.08 | 0.10 | 0.95 | No |
| CIN11 | 3.75 | 1.00 | 1.25 | 0.10 | 0.95 | No |
| VCU01 | 3.60 | 0.68 | 0.91 | 0.09 | 0.94 | Yes |
| VCU02 | 4.30 | 1.37 | 0.88 | 0.08 | 0.94 | No |
| VCU03 | 4.74 | 0.04 | 0.82 | 0.07 | 0.98 | No |
| VCU04 | 4.71 | 0.50 | 1.24 | 0.17 | 0.95 | No |
| VCU05 | 4.70 | 0.76 | 1.31 | 0.04 | 0.97 | No |
| NYU01* | 4.91 | 0.97 | 0.68 | (last data pt at wk1) | No | |
|
| ||||||
| mean | 4.53 | 0.70 | 0.95 | 0.06 | 0.97 | |
| SD | 0.60 | 0.37 | 0.24 | 0.04 | 0.02 | |
| Mean in patients with an ALT flare | 4.67 | 0.72 | 0.75** | 0.03** | 0.97 | |
| Mean in patients without an ALT flare | 4.44 | 0.69 | 1.08 | 0.08 | 0.96 | |
*
CIN04 and NYU01 were considered outliers and were not included in the calculation of the means.
**
Both δ (P=0.026) and δM (P=0.028) were significantly different in patients with ALT flare vs no flare.