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Relationship between different PKU phenotypes and (a) mean FoldX value (rs (70)=−0.446, P<0.001); (b) mean SNPs3D value (rs (89)=0.479, P<0.001); (c) mean PolyPhen-2 value (no relationship); and (d) mean SIFT values (no relationship). Error bars represent the 95% confidence interval.
