Table 2.

Effect of HLA locus matching on acute GVHD and chronic GVHD in a multivariable competing risk regression model

HLA	Match or mismatch*	N	Acute GVHD (Grade III-IV)†			Acute GVHD (Grade II-IV)†			N	Chronic GVHD‡
			RR	95% CI	P	RR	95% CI	P		RR	95% CI	P
A	Match	7048	1.00		.001	1.00		.002	5892	1.00		.328
	Mismatch	850	1.29	1.10-1.51		1.18	1.06-1.32		636	1.06	0.94-1.21
B	Match	7475	1.00		.001	1.00		.001	6217	1.00		.235
	Mismatch	423	1.42	1.16-1.73		1.28	1.11-1.48		311	1.10	0.94-1.30
C	Match	5565	1.00		<.001	1.00		<.001	4716	1.00		<.001
	Mismatch	2333	1.63	1.45-1.83		1.27	1.17-1.37		1812	1.24	1.13-1.35
DRB1	Match	5878	1.00		.022	1.00		<.001	4936	1.00		.262
	Mismatch	2020	1.21	1.03-1.43		1.24	1.11-1.39		1592	0.93	0.82-1.05
DQB1	Match	5681	1.00		.336	1.00		.126	4758	1.00		.018
	Mismatch	2217	1.08	0.92-1.27		1.09	0.98-1.22		1770	1.15	1.03-1.30
DPB1	Match	2604	1.00		.001	1.00		<.001	2223	1.00		.367
	Mismatch	5294	1.23	1.09-1.38		1.36	1.26-1.47		4305	1.04	0.96-1.12

RR of respective HLA locus mismatches at the allele level was compared with HLA match adjusted with other HLA locus matching and clinical factors as listed in Table 1.

CI, confidence interval.

^*GVH direction.

^†Survived 7 or more days.

^‡Survived 100 or more days.