Table 5.
Effect of chronic GVHD and HLA-DPB1 matching on leukemia relapse
| N | RR | 95% CI | P | |
|---|---|---|---|---|
| HLA-DPB1 | ||||
| Match* | 804 | 1.00 | ||
| 1-allele mismatch* | 971 | 0.70 | 0.58-0.84 | <.001 |
| 2-allele mismatch* | 354 | 0.54 | 0.41-0.72 | <.001 |
| Chronic GVHD | ||||
| No | 1232 | 1.00 | ||
| Limited type | 345 | 0.56 | 0.42-0.74 | <.001 |
| Extensive type | 552 | 0.46 | 0.36-0.58 | <.001 |
Multivariate competing risk regression analysis including HLA-DPB1 matching and chronic GVHD was performed by treating chronic GVHD as a time-dependent covariate adjusted for the clinical confounders listed in Table 1.
*
GVH direction.