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Inhibitory effects of rifampicin (left panel) and telmisartan (right panel) on the uptake of HMME mediated by OATP1B1 (A), OATP1B3 (B), and OATP2B1 (C). The HMME concentration was 1 μmol/L, and the uptake time was 30 s. Transporter-mediated HMME accumulation was corrected by subtracting the nonspecific accumulation in the mock-transfected HEK293 cells from that in the OATP-expressing HEK293 cells. Mean±SD. n=3.
