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. 2014 Nov 24;36(2):268–280. doi: 10.1038/aps.2014.104

Figure 5.

Figure 5

Concentration-dependent uptake of HMME-1 (A), HMME-2 (B), and HMME (C) into OATP-expressing HEK293 cells. The uptake time was 30 s. (A, B) The concentration-dependent uptake of each HMME isomer was represented by a nonlinear fitting curve and Eadie-Hofstee plots. (C) Accumulation of HMME-1 (circles) and HMME-2 (squares) in HEK293 cells were determined by exposing HMME to cells. Transporter-mediated HMME accumulation was corrected by subtracting the nonspecific accumulation in the mock-transfected HEK293 cells from that of the OATP-expressing HEK293 cells. Mean±SD. n=3. bP<0.05, cP<0.01 versus HMME-1 values.