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Uptake of HMME-1 and HMME-2 into adherent human hepatocytes (Lot LTG) in the absence or presence of transporter inhibitors. (A) The hepatic uptake of 2 μmol/L HMME were determined for 1 and 5 min at 37 °C and 4 °C. (B) Inhibitory effects of rifampicin (50 μmol/L, OATPs inhibitor), ketoprofen (10 μmol/L, OAT2 inhibitor), and MPP+ (10 μmol/L, OCT1 inhibitor) on the hepatic uptake of 2 μmol/L HMME was investigated at 37 °C for 10 min. Mean±SD. n=3. bP<0.05, cP<0.01 versus control values.
