Table 1. Pharmacokinetic analysis of a single intravenous dose of HMME (5 mg/kg) in rats pretreated with vehicle or 25 mg/kg rifampicin. Data are shown as the mean±SD. n=3. ^bP<0.05, ^cP<0.01 versus HMME-1 values. ^eP<0.05, ^fP<0.01 versus control values.

	Control			Rifampicin
	HMME-1	HMME-2	HMME	HMME-1	HMME-2	HMME
AUC0–8 h (h·μg/mL)	7.16±1.42	3.61±0.45b	10.7±1.9	12.1±1.9e	7.77±1.26f	19.9±3.1f
AUC0–∞ (h·μg/mL)	7.19±1.44	3.62±0.46b	10.8±1.9	12.2±1.8e	7.82±1.25f	20.1±3.0f
Cmax (μg/mL)	32.0±3.4	21.5±2.5b	53.6±5.9	36.1±4.4	31.6±5.1e	67.7±9.4
t1/2 (h)	1.72±0.39	1.48±0.31	1.70±0.30	2.39±0.52	1.81±0.47	2.34±0.52
Vz (L/kg)	0.86±0.04	1.47±0.15c	1.13±0.07	0.73±0.27	0.84±0.18f	0.88±0.35
CL (L·h−1·kg−1)	0.36±0.07	0.70±0.09c	0.47±0.08	0.21±0.03e	0.33±0.06f	0.25±0.04f
MRT (h)	0.39±0.07	0.36±0.03	0.39±0.08	0.60±0.10e	0.52±0.05f	0.58±0.09e