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Nutlin-3 causes IFI16 ectopic expression in a p53-dependent manner. (A) IFI16 subcellular localization was detected in HCC cells with different TP53 genotypes using fluorescence microscopy (1000×). Cells were treated as described above and stained for IFI16 (green). Nuclei were counter-stained with DAPI (blue). Images were merged using Image-Pro plus 6.0. (B) Proposed model for IFI16 subcellular localization regulated by Nutlin-3 in a p53-dependent manner in HCC cells.
