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. 2014 Dec 5;58(1):466–479. doi: 10.1021/jm501603h

Figure 1.

Figure 1

Left panel shows a DFG-in conformation of ABL kinase bound to dasatinib, with the Asp pointing in to the ATP binding site, and the right panel shows a DFG-out conformation of the ABL kinase domain bound to imatinib, with the Phe pointing into the ATP binding pocket. The binding pockets are shown in a mesh representation colored red. The DFG-out structure shows that Phe and Asp have swapped their positions in relation to DFG-in conformation. The flipped orientation also opens up an allosteric pocket highlighted in red dashes.