Skip to main content
. 2014 Dec 5;58(1):466–479. doi: 10.1021/jm501603h

Figure 3.

Figure 3

(A) Scatterplot of the D1 and D2 distances. D1 is the DFG Phe to Asn at HRD + 5 distance. D2 is the DFG Phe to salt-bridge Glu distance. The points are colored according to a k-means clustering with k = 4. (B) The same points are colored according to a cutoff scheme that recapitulates the black cluster shown in (A) {D1 ≤ 7.2; D2 ≥ 9.0}, while kinases labeled DFG-out by KLIFS26 and Zhao et al.29 but not contained in this box are shown in magenta. DFG-in and other kinases are shown in green.