Table 1. Structural Coverage of Classical DFG-Out Conformations in the PDB Based on Kinase Group and Subfamilies.
kinase group | total number of structures in the PDB for each group | number of kinase subfamilies represented in the PDB for each group | total number of subfamilies for each group in the kinome |
---|---|---|---|
AGC | 4 | 2 | 63 |
CAMK | 5 | 4 | 82 |
CMGC | 99 | 8 | 61 |
STE | 2 | 1 | 48 |
TK | 115 | 23 | 94 |
TKL | 20 | 4 | 43 |
CK1 | 0 | 0 | 12 |
other | 9 | 2 | 83 |
total | 257 | 44 | 486 |