TABLE 1.
BMD, three-dimensional micro-CT, and histological analysis of femur and histomorphometric analysis of lumbar spine from 9-month-old female Men1f/f and OC-Cre;Men1f/f mice
Tb, trabecular number; TbSp, trabecular separation; SMI, structure model index; TbTh, trabecular thickness; TbN, trabecular number; CtTh, cortical bone thickness; NS, not significant.
| Parameter | Men1f/f | OC-Cre;Men1f/f | Significance |
|---|---|---|---|
| BMD (g/cm2) | 0.078 ± 0.002 | 0.072 ± 0.001 | p < 0.05 |
| Micro-CT | |||
| BV/TV (%) | 5.38 ± 0.74 | 2.88 ± 0.29 | p < 0.05 |
| BS/BV (mm2/mm3) | 99.40 ± 0.71 | 78.78 ± 5.97 | p < 0.05 |
| BS/TV (mm2/mm3) | 5.34 ± 0.71 | 2.23 ± 0.04 | p < 0.05 |
| SMI | 2.17 ± 0.05 | 2.48 ± 0.09 | p < 0.05 |
| TbTh (mm) | 0.05 ± 0.003 | 0.07 ± 0.004 | p < 0.05 |
| TbN (1/mm) | 1.02 ± 0.14 | 0.43 ± 0.02 | p < 0.05 |
| TbSp (mm) | 0.34 ± 0.02 | 0.48 ± 0.02 | p < 0.01 |
| CtTh (mm) | 0.24 ± 0.004 | 0.20 ± 0.01 | p < 0.05 |
| Histomorphometry | |||
| BV/TV (%) | 14.44 ± 1.0 | 8.35 ± 0.76 | p < 0.01 |
| BS/TV (mm2/mm3) | 10.86 ± 1.1 | 6.58 ± 0.41 | p < 0.01 |
| BS/BV (mm2/mm3) | 74.39 ± 3.20 | 80.14 ± 4.42 | NS |
| TbTh (μm) | 27.19 ± 1.18 | 25.24 ± 1.31 | NS |