TABLE 2.
BMD, three-dimensional micro-CT and histological analysis of femur, and histomorphometric analysis of lumbar spine from 12-month-old female Col1a1-Menin-Tg and control mice
Tb, trabecular number; TbSp, trabecular separation; SMI, structure model index; TbTh, trabecular thickness; TbN, trabecular number; CtTh, cortical bone thickness; NS, not significant.
| Parameter | Control | Col1a1-Menin-Tg | Significance |
|---|---|---|---|
| BMD (g/cm2) | 0.067 ± 0.0007 | 0.07 ± 0.009 | NS |
| Micro-CT | |||
| BV/TV (%) | 0.93 ± 0.17 | 1.57 ± 0.09 | p < 0.05 |
| BS/BV (mm2/mm3) | 99.26 ± 7.52 | 96.36 ± 3.74 | NS |
| BS/TV (mm2/mm3) | 0.89 ± 0.12 | 1.51 ± 0.09 | p < 0.01 |
| SMI | 2.88 ± 0.08 | 2.63 ± 0.03 | p < 0.05 |
| TbTh (mm) | 0.06 ± 0.004 | 0.06 ± 0.0006 | NS |
| TbN (1/mm) | 0.15 ± 0.03 | 0.28 ± 0.01 | p < 0.05 |
| TbSp (mm) | 0.56 ± 0.01 | 0.50 ± 0.02 | NS |
| CtTh (mm) | 0.20 ± 0.01 | 0.19 ± 0.01 | NS |
| Histomorphometry | |||
| BV/TV (%) | 5.67 ± 0.41 | 7.51 ± 0.66 | p < 0.05 |
| BS/TV (mm2/mm3) | 4.32 ± 0.49 | 5.76 ± 0.47 | p < 0.05 |
| BS/BV (mm2/mm3) | 75.41 ± 3.96 | 77.32 ± 3.05 | NS |
| TbTh (μm) | 26.80 ± 1.32 | 26.04 ± 1.09 | NS |