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. 2014 Dec 4;290(7):3964–3971. doi: 10.1074/jbc.R114.581249

FIGURE 1.

FIGURE 1.

The SAM radical SPASM/Twitch subfamily similarity network. A, general mechanism for reductive cleavage of SAM by inner sphere electron transfer from the [4Fe-4S] to the C–S bond, forming a 5′-deoxyadenosyl radical and methionine. B, Protein Sequence Similarity Network (60) of the SPASM/Twitch domain containing proteins of the SAM radical superfamily. The nodes represent protein sequences with 40% sequence identity at an E-value (Expectation or Expect value) of 1 × 10−22. Proteins with SPASM domains map to 153 nodes (green dots). This figure was generated using Cytoscape (61).