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. 2014 Dec 23;290(7):4022–4037. doi: 10.1074/jbc.M114.617787

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FIGURE 10. — A and B, inhibition of acute TNF-induced liver inflammation by TROS in humanized transgenic mice. TNF (6.7 mg/kg) was injected in uPA^+/+-SCID mice with partially humanized liver (n = 9) pretreated with vehicle. This resulted in a significant increase of human IL8 expression in liver (A) and human IL6 levels (B) in serum after 2 h compared with mice injected with vehicle only (n = 6). Pretreatment with TROS (13.35 mg/ml) (n = 10) significantly antagonized inflammation in liver and serum. Data represent mean ± S.E., and statistical significances were calculated using an unpaired t test, comparing differences between vehicle only versus vehicle/TNF versus TROS/TNF. qPCR data were normalized to stable housekeeping genes.