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Library design and the His-435 loop. A, alignment of N3E-YTE mutations with corresponding wild-type IgG1 residues. Kabat EU numbering (30) is used; 437* designates an amino acid insertion after amino acid 437. The design of cysteine and charged libraries is shown (where X represents any amino acid and Z represents H, D, E, or Q). B, the His-435 loop (residues 432–437) of human IgG (wheat) is shown in complex with interacting residues on FcRn (gray; Protein Data Bank code 4N0U).
