FIGURE 8.

Immobilized IgLON family members promote neurite outgrowth in cortical neurons. A, outgrowth quantification of mature cortical neurons seeded on Fc-IgLON substrates (10, 50, and 100 μg/ml). Data were normalized to control Fc substrate. B, outgrowth quantification of mature cortical neurons seeded on IgLON substrates (100 μg/ml) and exposed to DMSO or BB-94. Data are shown as mean ± S.E., *, p < 0.05; **, p < 0.01; ***, p < 0.001 by one-way (B) and two-way (C) ANOVA, followed by Bonferroni post hoc test. C, schematic representation of the role of IgLON processing in neurite outgrowth.