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. 2014 Dec 28;290(7):4367–4382. doi: 10.1074/jbc.M114.605022

FIGURE 8.

FIGURE 8.

A model for regulation of bmal1b/Bmal1 by Per2/PER2 in zebrafish and mice. A, panel 1, in zebrafish, Rorα binds to RORE to activate bmal1b expression; panel 2, Rev-erbα outcompetes Rorα to repress bmal1b; panel 3, Per2 alone cannot reverse the inhibitory effect of Rev-erbα on bmal1b expression without the presence of Rorα; panel 4, Per2 alone can significantly enhance Rorα-mediated bmal1b expression; panel 5, Per2 enhances Rorα-mediated bmal1b transcription through binding to Rorα rather than Rev-erbα. B, panel 1, in mice, RORα binds to RORE to activate Bmal1 expression; panel 2, REV-ERBα outcompetes RORα to repress Bmal1; panel 3, PER2 alone cannot reverse the inhibitory effect of REV-ERBα on Bmal1 expression without the presence of RORα; panel 4, PER2 alone can significantly enhance RORα-mediated Bmal1 expression; panel 5, PER2 binds to REV-ERBα rather than RORα but enhances Bmal1 transcription still through RORα (arrow). C, panel 1, mouse PER2 alone enhances zebrafish Rorαa-mediated bmal1b transcription; panel 2, mouse PER2 cannot reverse the inhibitory effect of zebrafish Rev-erbα on bmal1b expression in the presence of Rorαa; panel 3, mouse REV-ERBα outcompetes zebrafish Rorαa to repress bmal1b. D, panel 1, zebrafish Per2 alone enhances mouse RORαa-mediated Bmal1 transcription; panel 2, zebrafish Per2 cannot reverse the inhibitory effect of mouse REV ERBα on Bmal1 expression in the presence of RORα; panel 3, zebrafish Rev-erbα cannot outcompete mouse RORαa to repress Bmal1.