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Affinities of 2-AP for wild-type and mutant pbuE aptamer domains
| RNA | KD(app) (nm) | KD(rel)a |
|---|---|---|
| Wild-type | 300 ± 30 | 1.0 |
| U66C | 200,000 ± 10,000 | 660 |
| G52C,G53C | ND | |
| A48U | 2700 ± 300 | 9.2 |
| U49A | 880 ± 90 | 3.0 |
| A50U | 720 ± 120 | 2.4 |
| U51G | 870 ± 90 | 2.9 |
a KD(rel) = KD(app)(mutant)/KD(app)(WT); ND, not detectable.
