FIGURE 8.

Model showing the regulation of Ski protein by TGF-β signaling and actin polymerization in hepatocytes. All Ski protein pools (nuclear and cytoplasmic) are similarly sensitive to down-regulation induced by TGF-β or actin polymerization independently of Ski subcellular localization (left panel). Intriguingly, cytoplasmic Ski protein stability regulated by the actin cytoskeleton dynamics depends on Ski-actin complex association, and the pool of Ski protein localized at lipid raft-rich vesicles seems to be protected from degradation induced by actin polymerization (right panel). (P = phosphate; Act = actin; Ub = ubiquitin).