Table 1.

Aging features quantified following p16 induction in CMV-rtTA mice d20-40^†

	Littermate controls†††		Bitransgenics
	N	Mean ± SD	N	Mean ± SD	%‡‡‡	Significance§§§
Hair density‡	14	12.3 ± 1.7	9	3.1 ± 0.8	25	P = 0.0001
Hair diameter§	3	1.27 ± 0.16	3	0.75 ± 0.05	59	P = 0.03
Body weight¶	17	19.6 ± 2.5	8	17.3 ± 2.9	89	P = 0.02
SI length††	17	26.9 ± 3.3	8	21.9 ± 3.6	81	P = 0.002
Colon length‡‡	17	6.0 ± 0.6	8	4.9 ± 0.7	82	P = 0.0006
Hematocrit§§	13	57 ± 8.4	8	53 ± 4.3	92	P = 0.18
Myeloid fraction¶¶	9	6.0 ± 6.8	6	12.8 ± 7.3	210	P = 0.02

^†All scoring was blinded to the mouse genotypes.

^‡mg/cm² shaved from mid-back.

^§Arbitrary units, hair shaved from mid-back; a total of 309 hairs scored

^¶g, males and females combined; males alone also significantly different.

^††cm

^‡‡cm

^§§% Packed blood cell volume.

^¶¶% Myeloid cells among white blood cells in blood smears.

^†††Wt and single transgene results did not differ significantly and were pooled.

^‡‡‡Bitransgenic value as % of control.

^§§§By Wilcoxon tests.