Table 2.

Single-SNP analysis in the Discovery sample of FOXO3Avariation and (A) activity of daily living and (B) bone (femur/spine/hip/wrist) fracture

(A) Activity of daily living (n = 1086)				(B) Bone fracture (n = 1063)
SNP	β-coef.	p-SNP	95% CI	SNP	OR	p-SNP	95% CI
rs9400239	0.07	0.020	0.01; 0.14	rs9486902	0.60	0.001	0.45; 0.81
rs9398172	0.07	0.021	0.01; 0.14	rs7762395	0.57	0.001	0.42; 0.78
rs13217795	0.07	0.024	0.01; 0.14	rs479744	0.69	0.007	0.52; 0.90
rs2802292	0.07	0.026	0.01; 0.13	rs3800231	0.72	0.008	0.57; 0.92
rs2764264	0.07	0.042	0.01; 0.13	rs9398172	0.74	0.012	0.58; 0.94
rs479744	0.07	0.055	−0.01; 0.14	rs9400239	0.75	0.017	0.59; 0.95
rs3800231	0.06	0.063	−0.01; 0.12	rs2764264	0.75	0.020	0.59; 0.96
rs7762395	0.07	0.074	−0.01; 0.15	rs13217795	0.76	0.028	0.60; 0.97
rs10499051	0.08	0.133	−0.02; 0.18	rs12206094	0.77	0.035	0.61; 0.98
rs12206094	0.05	0.149	−0.02; 0.11	rs2802292	0.80	0.049	0.64; 0.99
rs9486902	0.05	0.171	−0.02; 0.13	rs13220810	0.88	0.303	0.70; 1.12
rs3800232	0.04	0.392	−0.05; 0.13	rs12207868	1.17	0.362	0.83; 1.65
rs12207868	0.01	0.828	−0.09; 0.11	rs10499051	1.12	0.549	0.78; 1.61
rs12212067	0.01	0.869	−0.09; 0.10	rs3800232	0.94	0.711	0.68; 1.30
rs13220810	-0.01	0.905	−0.07; 0.06	rs12212067	1.03	0.874	0.73; 1.45

The single-SNP tests were the basis of the gene-set analysis in the Discovery sample. n, number of individuals with data; β-coef., beta coefficient; OR, odds ratio; CI, confidence interval; p-SNP values < 0.05 are shown in bold, while p-SNP values > 0.05 < 0.10 are shown in bold and italics.