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. 2014 Jul 25;13(6):965–974. doi: 10.1111/acel.12257

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© 2014 The Authors. Aging cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Network analysis. (A) Network of RKPM values of all expressed genes based on Pearson's correlation r ≥ 0.95, spring-embedded layout weighted on correlation. Color of nodes indicates the edge degree value with red assigned to nodes of highest values. Only the cluster with largest number of nodes is shown. (A′) Enlargement of (A): ZNF367, the node of highest edge, is indicated by yellow square, the position of KRCP, a gene of high edge degree value that was further studied by in situ hybridization, is indicated by a blue square. (B) Network of the first neighbors of ZNF367, 192 nodes, 1030 edges. The position of ZNF367 is indicated by a yellow arrow. (C) Gene enrichment analysis of ZNF367 first neighbors.