Figure 1.

Weekly body weight during the experiment. Absolute body weights. Nine-month-old male mice were divided into five groups: low-fat (LF) diet control mice and four high-fat (HF) diet groups: untreated control (HF), R1 – 1.5 mg kg⁻¹ rapamycin three times/week every other week; R2 group – 1.5 mg kg⁻¹ per a week every week and R3 group – 0.5 mg kg⁻¹ three times/week every other week. Treatment was continued for 11 months, and weight was measured every week. Upper panel – average weights for each group are presented. Bottom panel – schemas of rapamycin treatment schedules and photos of representative mice from low-fat and high-fat control groups are shown.