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Effects of daumone on insulin sensitivity in aged mice. (A) Intraperitoneal glucose tolerance test (IPGTT) was performed at day 140 after daumone administration. (B) The area under the curve (AUC) for IPGTT was calculated. (C) Immunoblots were conducted and quantitated. Data are presented as the mean±SE of 7-17 mice/group. *P < 0.05 vs. Y, †P < 0.05 vs. O. JNK, c-Jun N-terminal kinase; GSK, glycogen synthase kinase; Y, young mice; O, old mice; O+D, old mice treated with daumone.
